A rare bone marrow failure disease caused by low blood cell counts.
A type of therapy
An antibody based therapy that is aimed at Lymphocytes (A type of white blood cell and key part of the immune cell that attacks the stem cells in the bone marrow). This therapy is commonly used as part of the preparatory treatment before the stem cell transplant.
Amanda joined the AAT's Board of Trustees in April 2020 and became our chair in October the same year.
Amanda is an executive coach, working with leaders and managers, mainly in the arts, education and the third sector. Previously she had been editorial director at Heinemann publisher and MD of the literary estate of Roald Dahl. While there she developed and had responsibility for two charities, Roald Dahl’s Marvellous Children’s Charity, a grant-making foundation working to improve the lives of seriously ill children, and the Museum and Story Centre which bears the author’s name, of which she became chair. Amanda’s commitment to our work is founded on the experience of her daughter, who was diagnosed with Aplastic Anaemia in 2019. She is also a volunteer prison representative for the Shannon Trust, which aims to transform peoples’ lives by encouraging prisoners who can read to teach literacy skills to those who cannot.
A number of drugs that can be used to help fight/stop fungal infections. Examples of these drugs are amphotericin, posaconazole, fluconazole, voriconazole and nystatin.
ATG is a purified serum that suppresses the immune system to allow the bone marrow time to recover. It is produced by injecting animals (horse or rabbit) with white blood cells called lymphocytes. The animal then makes antibodies which are collected and purified to produce globulin.
ATG can either be used ahead of a stem cell transplant (rabbit) or with ciclosporin as a stand-alone treatment to let the bone marrow recover.
A small sample of bone marrow taken for examination
A small bit of bone marrow that is taken under local anaesthetic from either the hip bone or breast bone. The sample is then examined by microscope for abnormalities in the young blood cells.
Bone marrow biopsy and trephine sample
A small section of bone is taken under anaesthetic from either the hip or breast bones for examination. This is usually performed at the same time as the aspirate is taken.
A temporary thin tube
A temporary thin tube put into the vein for the giving of fluids or intravenous drugs, or for taking of blood samples.
A central catheter/line
A central venous catheter, more commonly called a central line or HICKMAN line is a small flexible plastic tube put into the large vein somewhere above the heart. This is used for giving fluids/drugs or for taking blood samples.
An immunosuppressant drug
Is an immunosuppressant drug which can be used for the treatment of aplastic anaemia.
Umbilical cord blood
Blood from the umbilical cord taken at the time of birth. This source of blood is very high in stem cells and can be used as a stem cell source for a stem cell transplant.
A reduction in the number of mature blood cells
There are several types of cytopenia depending on what type of blood cells are depleted:
Dagmara joined the AAT in 2018 to build a Trusts & Foundations income stream. In 2020 her role evolved to include impact management.
Typically, Dagmara’s work involves gathering evidence of need to support future projects and initiatives of the charity, developing compelling cases for support, researching funding opportunities and partnerships, putting strong grant applications, nourishing relationships and connections that matter, using best practice in monitoring and evaluation to plan and measure the impact of the AAT’s work.
Before joining the AAT, for many years Dagmara has worked in business development roles for consulting companies in the UK and abroad specialised in technology, innovation and international development.
In the AAT, Dagmara discovered the beauty of working in a small team that delivers work that no other organization in the UK does. She loves learning about patients’ needs and building funding propositions that address them.
A type of curative therapy
Treatment with the potential of restoring the bone marrow function so that patients can become transfusion-free, at less risk of infection/bleeding and live a more normal lifestyle.
Anita is a Consultant in Clinical Haematology, Lead Consultant for National PNH Service in England, St James Hospital, Leeds
Dominic is a a Consultant Haematologist, Honorary Senior Lecturer at Aberdeen Royal Infirmary and The University of Aberdeen
Keith is a Senior Lecturer, Honorary and Consultant Haematologist, Clinical Lead for Blood and Bone Marrow Transplantation, at the Cardiff and Vale University Health Board
Muhammad is a Consultant Haematologist at the Manchester Royal Infirmary
Sally is a Consultant Haematologist at the Royal Bournemouth Hospital
Sujith joined the AAT's Board of Trustees in November 2019.
Dr Sujith Samarasinghe is a consultant paediatric haematologist at Great Ormond Street Hospital, London. He completed his medical training at Imperial School of Medicine, London in 1998. He did his paediatric haematology training at Great Ormond Street Hospital and University College Hospital, London. He was awarded a PhD in 2010 from University College London in the field of immunotherapy for leukaemia.
In 2011, Sujith was appointed as a consultant haematologist in Newcastle but returned to Great Ormond Street Hospital in 2014. His areas of expertise include childhood leukaemia and aplastic anaemia. He is the national lead for childhood aplastic anaemia and supportive care, and a co-investigator on two CAR T-cell studies in childhood leukaemia.
Sujith is a Consultant Paediatric Haematologist at the Great Ormond Street Hospital
Ellie currently works for us part-time to support with communications and fundraising.
Ellie joined the team part-time in 2020 to support our community with fundraising support and communications. She's been busy refreshing and promoting our valuable website information to make it more accessible to patients, and creating new newsletters to help our community stay informed.
Ellie previously worked as Digital Engagement Manager at Blood Cancer UK, before spending the past few years running comms and fundraising at a small international health charity, Child.org.
Ellie loves food and once appeared on a TV cooking show! She's passionate about helping charities to be bold, ambitious and inspiring. If you have a story to tell, Ellie would love to hear from you - you can email her at [email protected]. She usually works on Tuesdays, Thursdays and Fridays.