A rare bone marrow failure disease caused by low blood cell counts.
A type of therapy
An antibody based therapy that is aimed at Lymphocytes (A type of white blood cell and key part of the immune cell that attacks the stem cells in the bone marrow). This therapy is commonly used as part of the preparatory treatment before the stem cell transplant.
A number of drugs that can be used to help fight/stop fungal infections. Examples of these drugs are amphotericin, posaconazole, fluconazole, voriconazole and nystatin.
ATG is a purified serum that suppresses the immune system to allow the bone marrow time to recover. It is produced by injecting animals (horse or rabbit) with white blood cells called lymphocytes. The animal then makes antibodies which are collected and purified to produce globulin.
ATG can either be used ahead of a stem cell transplant (rabbit) or with ciclosporin as a stand-alone treatment to let the bone marrow recover.
A small sample of bone marrow taken for examination
A small bit of bone marrow that is taken under local anaesthetic from either the hip bone or breast bone. The sample is then examined by microscope for abnormalities in the young blood cells.
Bone marrow biopsy and trephine sample
A small section of bone is taken under anaesthetic from either the hip or breast bones for examination. This is usually performed at the same time as the aspirate is taken.
A temporary thin tube
A temporary thin tube put into the vein for the giving of fluids or intravenous drugs, or for taking of blood samples.
A central catheter/line
A central venous catheter, more commonly called a central line or HICKMAN line is a small flexible plastic tube put into the large vein somewhere above the heart. This is used for giving fluids/drugs or for taking blood samples.
An immunosuppressant drug
Is an immunosuppressant drug which can be used for the treatment of aplastic anaemia.
Umbilical cord blood
Blood from the umbilical cord taken at the time of birth. This source of blood is very high in stem cells and can be used as a stem cell source for a stem cell transplant.
A reduction in the number of mature blood cells
There are several types of cytopenia depending on what type of blood cells are depleted:
A type of curative therapy
Treatment with the potential of restoring the bone marrow function so that patients can become transfusion-free, at less risk of infection/bleeding and live a more normal lifestyle.
Anita is a Consultant in Clinical Haematology, Lead Consultant for National PNH Service in England, St James Hospital, Leeds
Dominic is a a Consultant Haematologist, Honorary Senior Lecturer at Aberdeen Royal Infirmary and The University of Aberdeen
Keith is a Senior Lecturer, Honorary and Consultant Haematologist, Clinical Lead for Blood and Bone Marrow Transplantation, at the Cardiff and Vale University Health Board
Muhammad is a Consultant Haematologist at the Manchester Royal Infirmary
Sally is a Consultant Haematologist at the Royal Bournemouth Hospital
Sujith is a Consultant Paediatric Haematologist at the Great Ormond Street Hospital
Elaine, who's the AAT's Treasurer, joined the Board as Trustee in January 2018
A type of drug used as part of treatment for aplastic anaemia
A drug to help stimulate platelets to grow in the bone marrow.
A different name for red blood cells
A different name for red blood cells.
Granulocyte colony stimulating factor
A drug designed to help white blood cell production.
Grazina joined the Aplastic Anaemia Trust in January 2018 as its new CEO
Grazina joined the AAT in January 2018 as its new CEO and brings with her extensive experience of patient-focused and innovative support provision, business strategy development, research and organisational excellence obtained in the not-for-profit and public sectors. Most recently, Grazina was the Group Director of Performance, Quality and Innovation at the Richmond Fellowship, a national mental health services provider, where she was instrumental in the organisation’s growth, improvement and journey towards greater user focus. Grazina lives in Cambridgeshire with her family and a dog, enjoys reading, the theatre, keeping fit and baking. You can contact Grazina on [email protected]
Helen joined us in July 2019 to lead the MarrowKidz programme development and implementation, thanks to funding from the National Lottery
Helen has over ten years’ experience working in the UK not-for-profit sector at management level. As Education and Training Manager at Lymphoma Action, Helen was responsible for developing and delivering education events and courses for both healthcare professionals and for people personally affected by lymphoma. Most recently, Helen headed up the Health Promotion and Education team at Bowel Cancer UK, leading a team of five staff and over 80 volunteers with a lived experience of the cancer.
Helen lives in Buckinghamshire with her husband and two children.