Research news and updates

Mutation Timing and Clonal Trajectories in Aplastic Anaemia

The Aplastic Anaemia Trust will fund a new research project, investigating genetic mutations in patients with aplastic anaemia or PNH. Read more

RACE trial: Does eltrombopag improve outcomes for severe and very severe aplastic anaemia patients?

Read the new plain language summary of the RACE trial to learn more about how taking eltrombopag alongside treatment with horse ATG and ciclosporin has been shown to lead to faster treatment response for people with severe and very severe aplastic anaemia. Read more

TIARA Clinical trial of new aplastic anaemia treatment now recruiting patients

The TIARA trial at King’s College Hospital in London is now recruiting adult patients to trial a brand new potential treatment. Could you help? Find out if you could meet the criteria, and how to take part. Read more

Covid vaccination research is published in The Lancet Haematology

We are very proud to announce that the recent Leeds Covid vaccination study, funded by The Aplastic Anaemia Trust, has been published today in The Lancet Haematology. Read more

The AAT funds new research into COVID-19 vaccination responses in patients with aplastic anaemia and PNH

The new study will shed light on the question of how effective the Covid-19 vaccines are in aplastic anaemia patients. Read more

Do people with aplastic anaemia and/or PNH respond to the Covid-19 vaccines? Our research indicates, YES!

On December 6th, The Aplastic Anaemia Trust community received this update from the research team in Leeds about their study into the Covid-19 vaccine and people with aplastic anaemia and PNH. Watch the full presentation here! Read more

Update on the production of expanded autologous regulatory T cells to treat patients with refractory aplastic anaemia

Good progress made up until the Covid-19 crisis. Work set to resume once lockdown restrictions have been eased. Read more

Novel somatic mutations in aplastic anaemia patients

Update on a project led by the researchers at King’s College Hospital/King’s College London, funded by the AAT, April 2020 Read more

Update on the establishment of paediatric aplastic anaemia registry and biobank

A project run by researchers at Great Ormond Street Hospital, London, funded by the AAT and its generous supporters Read more

Compelling case for upfront HLA-matched unrelated donor stem cell transplant as a curative treatment fo adult SAA

Funds from Bloodwise, Cancer Research UK and the AAT, enable Professor Judith Marsh and colleagues to make a compelling argument. Read more

Why it's vital to have a better understanding of Aplastic Anaemia

Adult Aplastic Anaemia patients registry funded by the AAT discovered some interesting findings Read more

Results of an early study of CXCR4-blocking drug BL-8040, combined with immune-suppressive therapy

Encouraging to see new compounds being tested in the treatment of aplastic anaemia, narrated by Dr Laura Jardine, Newcastle University Read more

Study into success rates of half-matched stem cell transplant compared with standard first-line treatment of young patients with severe aplastic anaemia

Update from researchers in China, narrated by Laura Jardine, Newcastle University Read more

Eculizumab used in the treatment of PNH

A final piece of news from the 23rd Annual Congress of the European Haematology Association on the use of Eculizumab in PNH Read more

Phase 1 study on combining BL8040 compound with IST

News from the 23rd Annual Congress of the European Haematology Association on an exciting study taking place at the MD Anderson Cancer Centre in Texas Read more