Aplastic anaemia can be acquired or inherited. Inherited bone marrow failures include dyskeratosis congenita, fanconi anaemia, and others.
Aplastic anaemia can also lead to paroxysmal nocturnal haemoglobinuria (PNH), and vice versa, as in our experience some patients with PNH may later develop aplastic anaemia.
Here is a visual representation of inter-connections between different bone marrow failures.
PNH is a rare blood disorder where blood cells are prone to be attacked by the body’s immune system.
Dyskeratosis congenita is an inherited type of aplastic anaemia causing premature ageing due to telomere repair abnormalities.
Fanconi anaemia is a complex medical condition that may lead to bone marrow failure, physical abnormalities, organ defects, and an increased risk of certain cancers.