How is aplastic anaemia classified?

The degree to which the bone marrow fails varies greatly from non-severe (NSAA) through severe (SAA) to very severe (VSAA).

It is important to know the severity of the disease as this acts as a guide as to which type of treatment is most likely to produce the best result for a particular patient. The loss of the stem cell function can be gradual and the degree of marrow failure may change over time in a given patient. Sometimes signs and symptoms emerge slowly and progress over time.


Types of aplastic anaemia

Non- severe aplastic anaemia (NSAA). Sometimes referred to as moderate aplastic anaemia

The blood counts are low with a hypoplastic  bone marrow (having a low amount of blood forming tissue) but the condition is not severe enough to meet the criteria for severe aplastic anaemia

Severe aplastic anaemia

Bone marrow cellularity is either less than 25%, or 25-50% with less than 30% of stem cells in bone marrow and any two of the following:


·      An absolute neutrophil count of less than 0.5

·      A low platelet count (less than 20)

·      A reticulocyte count of less than 60


Very severe aplastic anaemia (VSAA)

As for severe aplastic anaemia but with an absolute neutrophil count of less than 0.2



What are the treatments?